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Pyrroloquinoline Quinone

Pyrroloquinoline Quinone

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PQQ (Pyrroloquinoline Quinone) is a leading edge supplement that offers remarkable benefits for a versatile range of uses, in particular energy. PQQ stimulates the growth and replication of new mitochondria. Stronger mitochondria, and more of them, produce more ATP (our energy source at the cellular level) and thereby, users of PQQ may feel higher levels of natural energy.

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Possible Benefits

  • Enhances cognitive function
  • Improves short-term memory
  • Prevent memory loss and cognitive decline
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Required Equipment

Pyrroloquinoline Quinone

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How to Do It

Take a PQQ supplement each morning. For new users, it is recommended to start at a dosage of 10-20mg per day

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Why it works

  • Pyrroloquinoline quinone (PQQ) has been identified as a novel supplement that is involved in many bodily processes including redox modulation, cellular energy metabolism, and mitochondrial biogenesis. PQQ also has antioxidant potential. It helps the body produce energy at the cellular level (within the mitochondria) and supports the creation of new mitochondria as well, thereby increasing the output of energy even further.
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Time Commitment

2-5 minutes 

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Suggested Frequency

5 times per week

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Time of Day


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Possible Side Effects

Side effects aren’t fully known, however we do know that PQQ poses a risk of kidney damage when taken at very high doses. As such, you shouldn’t take more than the amount recommended on the packaging. Consult your healthcare provider prior to adding PQQ to your supplement regimen, especially if you’re taking any prescription medications.

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  • PQQ can often be found in combination with other supplements on this list, thereby reducing the amount of capsules you would have to take each day
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Supporting Studies and Articles

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  1. Saihara K, Kamikubo R, Ikemoto K, Uchida K, Akagawa M. Pyrroloquinoline Quinone, a Redox-Active o-Quinone, Stimulates Mitochondrial Biogenesis by Activating the SIRT1/PGC-1α Signaling Pathway. Biochemistry. 2017;56(50):6615-6625. doi:10.1021/acs.biochem.7b01185
  2. Chowanadisai W, Bauerly KA, Tchaparian E, Wong A, Cortopassi GA, Rucker RB. Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression. J Biol Chem. 2010;285(1):142-152. doi:10.1074/jbc.M109.030130
  3. Kuo YT, Shih PH, Kao SH, Yeh GC, Lee HM. Pyrroloquinoline Quinone Resists Denervation-Induced Skeletal Muscle Atrophy by Activating PGC-1α and Integrating Mitochondrial Electron Transport Chain Complexes. PLoS One. 2015;10(12):e0143600. Published 2015 Dec 8. doi:10.1371/journal.pone.0143600
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