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Alpha-GPC (Choline alfoscerate) is a popular nootropic known for its ability to increase serotonin and dopamine. It is part of the choline group, which is key for optimal cognitive function.

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Possible Benefits

  • May improve focus
  • May enhance learning
  • May improve physical performance
  • May boost motivation
  • May improve athletic recovery 
  • May improve mood
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Required Equipment

Alpha-GPC supplement.

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How to Do It

Take the Alpha-GPC supplement according to the manufacturer’s instructions. Usually, the dosage is up to 600mg per day.

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Why it works

  • It is especially efficient due to its ability to cross the blood-brain barrier, making it a better than other choline sources and even choline itself at increasing available levels of choline for the brain.
  • It also has neuroprotectant qualities and it is being investigated for increasing human growth hormone.
  • Usually, users experience the effects quickly, within the first hour after consumption.
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Time Commitment

1 minute 

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Suggested Frequency

According to the manufacturer’s instructions

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Time of Day


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Possible Side Effects

Headaches, fatigue, nervousness, nausea, diarrhea, and gastrointestinal distress.

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  • Stack with lion’s mane, noopept and racetams to get better results. 
  • Check out our nootropics guide to learn more about choline and how it is crucial for cognitive function. 
  • If you exercise or practice sports regularly, Alpha-GPC is ideal to improve your performance and promote physical recovery.
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Related Products

Lion’s mane, nootropics.

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Supporting Studies and Articles

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  1. The effects of alpha-glycerylphosphorylcholine, caffeine or placebo on markers of mood, cognitive function, power, speed, and agility. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595381/
  2. Effect of a new cognition enhancer, alpha-glycerylphosphorylcholine, on scopolamine-induced amnesia and brain acetylcholine. https://pubmed.ncbi.nlm.nih.gov/1662399/
  3. Nootropic drugs and brain cholinergic mechanisms. https://pubmed.ncbi.nlm.nih.gov/2694231/
  4. Pre-clinical evaluation of cognition enhancing drugs. https://pubmed.ncbi.nlm.nih.gov/2694232/
  5. Alpha-GPC and Physical and Cognitive Performances in Volleyball Players. (VolleyAGPC). https://clinicaltrials.gov/ct2/show/NCT02886130
  6. Choline Alphoscerate (Alpha-Glyceryl-Phosphoryl-Choline) An Old Choline- containing Phospholipid with a Still Interesting Profile As Cognition Enhancing Agent. https://www.researchgate.net/publication/258041903_Choline_Alphoscerate_Alpha-Glyceryl-Phosphoryl-Choline_An_Old_Choline-_containing_Phospholipid_with_a_Still_Interesting_Profile_As_Cognition_Enhancing_Agent
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