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Sunifiram is a popular nootropic and it is part of the ampakines group. Ampakines increase the glutamate available in your brain. This is key because glutamate is a neurotransmitter present in almost every chemical reaction in your brain.

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Possible Benefits

  • May boost cognitive function
  • May improve memory
  • May boost energy
  • May enhance your learning
  • May increase motivation
  • May improve mood
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Required Equipment

Sunifiram powder or capsules

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How to Do It

Take the powder or capsules according to the manufacturer’s instructions.

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Why it works

  • By increasing glutamine in the brain, it helps to amplify long term potentiation and improve long term connections between synapses. This is especially useful for working memory and perception. 
  • Its effect is much more powerful than the well-known piracetam, a famous nootropic used to improve memory.
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Time Commitment

1 minute

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Suggested Frequency

According to the manufacturer’s instructions. 

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Time of Day


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Possible Side Effects

Increased body temperature

Increased salivation



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  • Stack with Aniracetam, Alpha-GPC and/or Vitamin B6 to get even better results. 
  • The effect lasts 2-5 hours. 
  • If Sunifiram doesn’t work well for you, try a different ampakine. 
  • Get professional advice when consuming this and other nootropics.
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Related Products


Vitamin B Complex


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Supporting Studies and Articles

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  1. DM235 (sunifiram): a novel nootropic with potential as a cognitive enhancer. https://pubmed.ncbi.nlm.nih.gov/12070754/
  2. Novel nootropic drug sunifiram improves cognitive deficits via CaM kinase II and protein kinase C activation in olfactory bulbectomized mice. https://pubmed.ncbi.nlm.nih.gov/23295391/
  3. Pharmacological characterization of DM232 (unifiram) and DM235 (sunifiram), new potent cognition enhancers. https://pubmed.ncbi.nlm.nih.gov/16834757/
  4. Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators. https://pubmed.ncbi.nlm.nih.gov/18954993/
  5. Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers. https://pubmed.ncbi.nlm.nih.gov/19786353/
  6. Structure-activity relationship studies on unifiram (DM232) and sunifiram (DM235), two novel and potent cognition enhancing drugs. https://pubmed.ncbi.nlm.nih.gov/14697772/
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 Happiness  Energy  Productivity  Memory  Sharpness  Motivation
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